AOD-9604
The Fat-Burning Peptide with Healing Potential
What is AOD9604?
AOD9604, short for “Advanced Obesity Drug 9604,” is a synthetic peptide fragment derived from human growth hormone (HGH). More specifically, it consists of amino acids 176–191 of the full HGH molecule. Despite being derived from HGH, AOD9604 is non-hormonal in nature and does not raise IGF-1 levels—making it a safer, more targeted option for those researching fat metabolism and weight loss support.
Originally developed as a potential treatment for obesity, AOD9604 has since attracted attention for its fat-burning potential, tissue repair benefits, and anti-inflammatory properties—without the side effects typically associated with growth hormone.
How Does AOD9604 Work?
Unlike full-length HGH, AOD9604 works by selectively mimicking the fat-reducing region of growth hormone. This region, made up of amino acids 176–191, is believed to be responsible for lipolysis (fat breakdown) and anti-lipogenesis (inhibition of fat formation).
Mechanism of Action:
- Stimulates lipolysis, encouraging the breakdown of stored fat
- Inhibits lipogenesis, reducing new fat accumulation
- May enhance metabolism without impacting muscle mass
- Does not significantly influence blood sugar levels or insulin
This mechanism allows AOD9604 to promote fat loss in a more targeted and controlled way than HGH itself.
Key Benefits of AOD9604
Research and anecdotal use have highlighted several potential benefits of AOD9604, particularly when combined with healthy lifestyle changes.
🔥 Fat Loss Support
- Promotes breakdown of stubborn fat stores
- May assist with visceral fat reduction
- Often used in targeted body recomposition protocols
🛠️ Joint & Cartilage Repair
- Shows potential in supporting cartilage regeneration
- May help reduce inflammation in joints
- Often stacked with BPC-157 or TB-500 for recovery support
💊 No Hormonal Disruption
- Does not elevate IGF-1 or growth hormone levels
- May be safer for individuals sensitive to hormonal shifts
- Appears well-tolerated with a low side effect profile
💪 Lean Mass Retention
- Encourages fat metabolism while preserving lean muscle
- Ideal for use during calorie deficits or cutting cycles
Usage & Dosage Guidelines
Common Use Case:
AOD9604 is typically used in peptide research focused on weight loss, metabolic health, and tissue repair.
Typical Dosage:
- 250mcg to 500mcg per day, often administered subcutaneously
- Can be taken once daily, preferably in the morning or pre-workout
- Cycle length often ranges from 4 to 12 weeks, depending on the goal
How to Administer:
- Administered via subcutaneous injection, usually in the abdominal area
- Best absorbed on an empty stomach
- May be used as a standalone peptide or stacked with fat-burning or recovery peptides
Always consult a qualified medical professional before beginning any peptide protocol.
AOD9604 vs HGH: What’s the Difference?
| Feature | AOD9604 | HGH (Human Growth Hormone) |
|---|---|---|
| Source | Fragment 176–191 of HGH | Full 191-amino acid HGH |
| Hormonal Activity | Non-hormonal | Strong hormonal effects |
| IGF-1 Elevation | No | Yes |
| Muscle Growth | Mild (indirect) | Strong |
| Fat Loss | Targeted | General |
| Side Effects | Very low | Higher risk (water retention, etc) |
| Injection Schedule | Daily, low dose | Daily or intermittent |
Safety Profile of AOD9604
AOD9604 has been evaluated in multiple clinical trials, particularly during its development as an obesity treatment. According to published research:
- Well tolerated in both animal and human trials
- No significant changes in glucose metabolism, IGF-1, or organ stress markers
- Low risk of side effects, even at higher doses
Common Side Effects (Rare):
- Mild redness at injection site
- Occasional headache or fatigue
- Transient bloating
Reference:
- E. Ng et al., “AOD9604, a Human Growth Hormone Fragment, Stimulates Lipolysis in Obese Men: A Randomized Controlled Trial.” Obesity Research, https://pubmed.ncbi.nlm.nih.gov/16339126/
- Therapeutic Goods Administration (TGA) Australia – AOD9604 safety summary, https://www.tga.gov.au/news/media-releases/decisions-aod-9604
How to Store AOD9604
- Store unreconstituted peptide powder in a cool, dry place or refrigerator (2–8°C)
- After reconstitution, keep refrigerated and use within 14–30 days
- Avoid shaking the vial aggressively—gently roll to mix
Tips for Peptide Integration
If incorporating AOD9604 into a research stack:
- Combine with CJC-1295 w/ DAC for growth hormone support without excessive spikes
- Stack with BPC-157 or TB-500 for joint and recovery synergy
- For fat loss: pair with a caloric deficit and moderate physical activity
AOD9604 may be best suited for morning use to support daily metabolic function.
Is AOD9604 Right for Your Research?
Whether you’re exploring non-hormonal weight loss agents or supporting healing post-injury, AOD9604 offers a promising alternative to more aggressive hormone-based peptides. It brings together the targeted fat-burning properties of growth hormone—without the hormonal risks.
As always, work with a licensed medical professional and conduct your own due diligence when considering peptide-based approaches.
Final Thoughts
AOD9604 is a highly specialized peptide with a strong safety profile and targeted action. For those looking to explore fat metabolism, joint health, or a smarter cutting stack, this compound has earned its place in the modern peptide toolbox.
Lab of RAD offers pure, research-grade AOD9604 in various sizes. Whether you’re a biohacker, formulator, or clinical researcher, we’re here to support the science.
⚠️ FDA Disclaimer
The information provided on this page is intended for research, educational, and informational purposes only. AOD9604 has not been evaluated or approved by the U.S. Food and Drug Administration (FDA) for medical use, treatment, or diagnosis. This peptide is not intended to diagnose, treat, cure, or prevent any disease. Always consult a healthcare provider before beginning any supplementation or research peptide protocol.
Lab of RAD products are sold for laboratory research use only and are not for human consumption.