AOD-9604

The Fat-Burning Peptide with Healing Potential

What is AOD-9604?

AOD-9604 (Advanced Obesity Drug 9604) is a modified fragment of human growth hormone (HGH), specifically the C-terminal end (amino acids 176–191). Unlike full-length HGH, AOD-9604 is non-anabolic, meaning it does not stimulate muscle growth or impact IGF-1 levels—but it retains and enhances the fat-burning properties of HGH. This makes AOD-9604 a compelling candidate for weight management, fat loss, and metabolic support, without the common side effects associated with growth hormone therapies.

Key Advantage: AOD-9604 stimulates lipolysis (fat breakdown) and inhibits lipogenesis (fat formation) without affecting blood sugar, insulin levels, or muscle growth.

The Science Behind AOD-9604

AOD-9604 was originally developed by Metabolic Pharmaceuticals in Australia in the early 2000s as an anti-obesity therapeutic. Researchers isolated the portion of HGH responsible for fat metabolism and synthesized it into a shorter peptide that was both more stable and safer for long-term use.

Preclinical studies and human trials demonstrated that AOD-9604:

  • Reduces body fat, particularly in abdominal and visceral regions
  • Increases fat oxidation
  • Does not affect IGF-1 levels or cause insulin resistance
  • May support cartilage regeneration and joint healing

Reference: Ng FM, et al. “The lipolytic actions of human growth hormone (hGH) are mediated by the C-terminal region of hGH.” J Endocrinol. 2000;167(2):317–327. doi:10.1677/joe.0.1670317

How It Works

AOD-9604 works by mimicking the way natural HGH regulates fat metabolism. Specifically, it activates beta-3 adrenergic receptors in adipose tissue, promoting the breakdown of stored fat while inhibiting the formation of new fat cells. It does this without stimulating the growth hormone receptor, which eliminates the risk of unwanted side effects like acromegaly, insulin resistance, or water retention commonly seen with HGH abuse.

Benefits of AOD-9604

  • Promotes fat loss (especially stubborn and visceral fat)
  • No effect on blood sugar or insulin levels
  • Non-anabolic—safe for long-term use
  • May support joint healing and cartilage repair
  • No known serious side effects in clinical studies

Clinical Data: A 2004 study published in “Obesity Research” showed that AOD-9604 significantly reduced body weight in obese subjects without adverse effects on glucose tolerance or other hormone levels.
Reference: Johannsson G, et al. “A double-blind, placebo-controlled study on the effects of the growth hormone fragment (AOD9604) in obese males.” Obes Res. 2004;12(5):734–739. doi:10.1038/oby.2004.89

Applications and Uses

Although originally studied for obesity treatment, AOD-9604 is increasingly used off-label in wellness and aesthetic medicine for:

  • Targeted body fat reduction
  • Metabolic enhancement
  • Support in weight loss regimens
  • Improved recovery from injury (due to potential cartilage and tissue repair effects)

AOD-9604 is commonly combined with other peptides like CJC-1295, Ipamorelin, or GHK-Cu in performance and body optimization protocols.

Dosing and Administration

AOD-9604 is typically administered as a subcutaneous injection, often in the abdominal area. Common dosing protocols range from 250–500 mcg per day, often taken in the morning or pre-workout. It may also be formulated into oral lozenges or transdermal preparations, although bioavailability is generally higher with injections.

Always consult with a medical professional before starting any peptide therapy.

Safety Profile

AOD-9604 has demonstrated a strong safety record in multiple human studies, with no significant adverse effects on liver enzymes, kidney function, cardiovascular markers, or hormonal balance. It has GRAS (Generally Recognized As Safe) status from the FDA for oral use, although its injectable form remains investigational in the United States.

Reference: U.S. FDA GRAS Notice No. GRN 000799

Conclusion

AOD-9604 represents a new generation of targeted peptides—offering the fat-burning and regenerative benefits of growth hormone without the associated risks. Whether you’re looking to support a weight loss journey, optimize your body composition, or enhance recovery, AOD-9604 is a smart, science-backed option for your peptide toolbox.