ARA-290
The Next Frontier in Inflammation Control and Nerve Repair
What is ARA290?
ARA290, also known as Cibinetide, is a synthetic peptide derived from erythropoietin (EPO), but without the erythropoietic (red blood cell-producing) effects. It is engineered to activate the innate repair receptor (IRR)—a specific receptor involved in anti-inflammatory and tissue-protective pathways—without impacting blood viscosity or hematocrit.
Originally developed to help treat chronic pain, inflammation, and neuropathy, ARA290 is now studied for its potential benefits in treating diabetic neuropathy, inflammatory conditions, autoimmune disorders, and even small fiber neuropathy. Unlike EPO, ARA290 offers tissue healing without the blood thickening, making it a standout peptide in regenerative and neuroprotective research.
How Does ARA290 Work?
ARA290 works by selectively binding to the innate repair receptor (IRR)—a receptor composed of the EPOR (erythropoietin receptor) and CD131. When activated, this receptor triggers anti-inflammatory and tissue-protective pathways, particularly in nerve cells and vascular tissue.
Mechanism of Action:
- Reduces inflammation in peripheral and central nervous systems
- Inhibits neurodegenerative processes
- Stimulates tissue regeneration and angiogenesis
- Does not activate classical EPO pathways, avoiding hematologic side effects
By targeting IRR instead of full EPO pathways, ARA290 can reduce pain and restore nerve function without impacting red blood cell production.
Key Benefits of ARA290
Researchers and early users have highlighted several benefits, especially in the areas of nerve protection and inflammation control.
🔥 Neuropathy and Nerve Repair
- Reduces neuropathic pain symptoms
- Improves nerve regeneration and conductivity
- Often studied in diabetic and small fiber neuropathy (SFN)
🧠 Anti-Inflammatory Effects
- Modulates immune system without suppressing it
- Reduces inflammatory cytokines like TNF-α and IL-6
- May help reduce inflammation in autoimmune and chronic pain conditions
❤️ Tissue Protection and Healing
- Promotes healing of vascular and nerve tissue
- Enhances angiogenesis and tissue oxygenation
- May support healing after injury or chronic inflammation
🚫 Non-Erythropoietic
- Unlike EPO, does not increase red blood cell count
- No impact on hematocrit or risk of thrombosis
- Considered safer for long-term use in inflammation management
Usage & Dosage Guidelines
Common Use Case:
ARA290 is used in research on chronic inflammation, neuropathy, and tissue healing. Also, ARA290 is also being investigated as a potential therapy for autoimmune disorders and long COVID-related SFN.
Typical Dosage:
- 2mg per day, typically administered subcutaneously
- Some protocols split this into 1mg AM and 1mg PM
- Typical research cycles range from 4 to 12 weeks, depending on condition
How to Administer:
- Subcutaneous injection, usually in the abdominal region
- May be paired with BPC-157 or TB-500 for additional healing synergy
Note: Always consult a qualified professional before initiating any peptide protocol.
ARA290 vs EPO: Key Differences
| Feature | ARA290 | Erythropoietin (EPO) |
|---|---|---|
| Receptor Target | Innate Repair Receptor (IRR) | EPO Receptor (EPOR) only |
| Increases RBCs | No | Yes |
| Neuroprotective | Yes | Some (with side effects) |
| Inflammation Control | Strong | Mild |
| Thrombosis Risk | Low | High (due to hematocrit changes) |
| Use Case | Tissue repair, neuropathy | Anemia, kidney failure |
Safety Profile of ARA290
ARA290 has been studied in human clinical trials, particularly in the context of diabetic neuropathy and SFN.
Safety Highlights:
- Well tolerated across multiple trials
- No effect on blood pressure, hematocrit, or renal markers
- No immunosuppression or hormonal disruption observed
Possible Side Effects (Rare):
- Mild injection site irritation
- Temporary fatigue or nausea in some cases
References:
- Brines, M. et al. “Cibinetide Improves Neuropathic Symptoms in Patients with Sarcoidosis-Associated Small Fiber Neuropathy.” Pain, 2018. https://pubmed.ncbi.nlm.nih.gov/29652662/
- Dahan, A. et al. “Targeting the innate repair receptor with ARA290 relieves neuropathic pain and improves functional nerve recovery.” Molecular Pain, 2014. https://molpain.biomedcentral.com/articles/10.1186/1744-8069-10-17
Storage Instructions
- Store peptide powder in a cool, dry place or refrigerator (2–8°C)
- Once reconstituted, refrigerate and use within 14–30 days
- Avoid exposure to heat, light, or contamination
Peptide Stacking Tips
ARA290 may be stacked in research protocols with:
- BPC-157 – for gut, tendon, and systemic recovery support
- TB-500 – for muscle repair and systemic tissue regeneration
- KPV or Thymosin Alpha-1 – for autoimmune/inflammatory conditions
Daily subcutaneous use alongside anti-inflammatory stacks may support systemic healing and enhanced nerve recovery.
Is ARA290 Right for Your Research?
If you’re investigating next-gen therapies for chronic inflammation, autoimmune dysregulation, or neuropathic pain, ARA290 deserves serious consideration. It provides EPO-level tissue protection without the EPO baggage.
Its favorable safety profile and broad range of effects make it a strong candidate for neuroregenerative and pain-reduction research.
Final Thoughts
ARA290 is a standout in the peptide space—targeting inflammation, restoring nerve function, and promoting tissue healing without triggering unwanted hormonal side effects. Whether you’re studying neuropathy, long COVID effects, or chronic joint pain, this compound may offer a molecular solution worth exploring.
Lab of RAD provides research-grade ARA290 for advanced formulation and peptide experimentation.
⚠️ FDA Disclaimer
The information provided here is intended for research, educational, and informational purposes only. ARA290 has not been evaluated or approved by the U.S. Food and Drug Administration (FDA) for human use, treatment, or diagnosis. This product is not intended to diagnose, treat, cure, or prevent any disease. Always consult a healthcare provider before beginning any supplementation or peptide protocol.
Lab of RAD peptides are sold strictly for laboratory research use only and are not for human consumption.