CJC-1295
The Growth Hormone Releasing Powerhouse
What is CJC-1295?
CJC-1295 is a synthetic peptide designed to mimic growth hormone-releasing hormone (GHRH). It helps increase the natural production of growth hormone (GH) by binding to the GHRH receptor in the pituitary gland. What sets this apart from other peptides is that it comes in two distinct forms: CJC-1295 with DAC and CJC-1295 without DAC.
Understanding the difference between these two is essential if you want to choose the right peptide for your research goals.
CJC-1295 With DAC vs Without DAC: What’s the Difference?
CJC-1295 with DAC (Drug Affinity Complex) has a significantly extended half-life—lasting up to 6–8 days. Without DAC, the peptide lasts only about 30 minutes to a few hours, making it shorter-acting and more pulse-driven.
| Feature | With DAC | Without DAC |
|---|---|---|
| Half-Life | 6–8 days | ~30 minutes–2 hours |
| Injection Frequency | 1–2 times per week | 1–2 times per day |
| GH Release Pattern | Steady, prolonged | Short, sharp pulses |
| Best Used For | Long-term GH support, anti-aging | Pulsed GH release, acute support |
| IGF-1 Increase | Yes | Yes, but shorter-lived |
| Stack Pairings | Works well with Ipamorelin | Works best with GHRP-6 or GHRP-2 |
| Convenience | High (fewer injections) | Low (requires frequent dosing) |
How CJC-1295 Works
Both versions work by stimulating the natural release of growth hormone through the pituitary gland. This leads to increased production of IGF-1, a powerful growth factor responsible for tissue regeneration, fat metabolism, and muscle recovery.
- With DAC: Delivers a slow, consistent release of GH over several days.
- Without DAC: Mimics natural GH pulses more closely with short bursts.
Benefits of CJC-1295 (With & Without DAC)
Shared Benefits:
- Supports lean muscle development
- Promotes fat metabolism
- Aids in recovery and tissue repair
- May improve sleep quality and cognitive clarity
- Enhances collagen production and skin elasticity
Unique to CJC-1295 With DAC:
- Greater convenience (fewer injections)
- More stable, long-term elevation of GH and IGF-1
- Ideal for anti-aging and long-term metabolic optimization
Unique to CJC-1295 Without DAC:
- Closer mimic of natural GH pulsatility
- Easier to fine-tune dosage and response
- Often preferred for short-term performance or recovery stacks
Dosage & Protocols
🔹 CJC-1295 With DAC
- Dosage: 1–2mg subcutaneously, once or twice weekly
- Cycle Length: 8–12 weeks recommended
- Timing: Can be taken at any time; consistent weekly schedule advised
🔹 CJC-1295 Without DAC
- Dosage: 100–300mcg 1–2 times daily
- Cycle Length: 6–12 weeks
- Timing: Best on an empty stomach, 30–60 minutes before meals or workouts
Both versions can be stacked with Ipamorelin, GHRP-6, or GHRP-2 to amplify growth hormone release.
Safety Profiles: What to Expect
Both forms are generally well tolerated. However, due to the difference in their duration of action, users may experience slightly different effects.
Shared Safety Insights:
- Minimal side effects when used properly
- Some users report mild water retention
- Injection site redness may occur
Additional With DAC:
- Rare cases of lethargy or appetite changes
- Slightly more IGF-1 buildup over time (which may often be a goal)
Additional Without DAC:
- More flexibility, but greater risk of missed doses
- Possible headache or light dizziness from acute GH spikes
Reference Study:
- Teichman et al., “Prolonged stimulation of GH and IGF-1 with CJC-1295 in healthy adults,” J Clin Endocrinol Metab, 2006. https://pubmed.ncbi.nlm.nih.gov/16352683/
What to Stack With CJC-1295
Both forms benefit from synergistic stacking:
- Ipamorelin – pairs well with both versions to enhance GH pulse
- BPC-157 or TB-500 – for deeper recovery and tissue healing
- GHK-Cu – for skin and connective tissue support
Choose your stack based on desired goals: fat loss, muscle gain, or regenerative focus.
How to Store CJC-1295
- Store lyophilized peptide in the refrigerator (2–8°C)
- Once reconstituted, keep refrigerated and use within 14–30 days
- Reconstitute with bacteriostatic water
- Do not shake the vial—gently roll to mix
Is CJC-1295 Right for Your Research?
If you’re researching growth hormone pathways, tissue regeneration, or body composition optimization, CJC-1295 with DAC is a great low-maintenance option. For more flexible, acute GH pulses, CJC-1295 without DAC provides tight control.
Both versions are powerful, adaptable, and research-friendly.
Final Thoughts
Whether you choose CJC-1295 with DAC for long-term hormonal support or without DAC for short-term GH pulses, this peptide is one of the most reliable tools in modern performance and wellness research.
Lab of RAD provides high-purity CJC-1295 (with and without DAC) for researchers seeking bold, molecular-level outcomes.
⚠️ FDA Disclaimer
All information provided is for educational and research purposes only. CJC-1295 is not approved by the FDA for human use. It is not intended to diagnose, treat, cure, or prevent any disease. Consult a healthcare professional before initiating any peptide research.
Lab of RAD peptides are for laboratory research use only and not for human consumption.