FOX04-DRI
Targeting Cellular Senescence for True Anti-Aging
What is FOX04-DRI?
FOX04-DRI is a synthetic peptide designed to selectively eliminate senescent cells—the “zombie” cells that accumulate with age and contribute to inflammation, tissue dysfunction, and age-related disease. Short for “Forkhead box O4 D-retro-inverso,” FOX04-DRI is engineered to interfere with the interaction between FOX04 and p53, thereby triggering apoptosis (programmed cell death) in damaged or senescent cells without harming healthy tissue.
This class of compounds is known as a senolytic peptide, and FOX04-DRI is one of the most promising peptides in the field of longevity and age-related research.
How Does FOX04-DRI Work?
In aging cells, the FOXO4 protein binds to p53, a tumor suppressor protein, and prevents it from initiating apoptosis. This leads to the survival of dysfunctional, non-dividing senescent cells that secrete inflammatory signals (the SASP: senescence-associated secretory phenotype).
FOX04-DRI disrupts this interaction, freeing p53 and allowing it to do its job—clearing out the cellular clutter.
Mechanism of Action:
- Targets senescent cells via FOXO4-p53 pathway
- Induces apoptosis only in senescent, damaged cells
- Reduces inflammation by limiting SASP factors
- Promotes tissue regeneration by clearing cellular debris
Benefits of FOX04-DRI
FOX04 is a peptide designed for regenerative medicine, healthy aging, and potentially for combating age-related chronic diseases.
🧬 Cellular Rejuvenation
- Eliminates senescent cells that contribute to aging
- Supports healthier tissue regeneration
- Promotes cleaner, younger cell populations
🔥 Reduced Inflammation
- Lowers secretion of inflammatory cytokines (SASP)
- May reduce systemic inflammation, joint pain, and oxidative damage
🧠 Neuroprotective Potential
- Senescent cell buildup has been linked to cognitive decline
- Early research suggests benefits for brain aging and recovery
💪 Muscle & Skin Health
- May help preserve muscle function with age
- Promotes skin health, elasticity, and structure by reducing senescence in dermal fibroblasts
Suggested Dosage & Protocol
FOX04-DRI is used primarily in research settings and protocols are still being refined. The following guidelines reflect early-stage best practices.
Typical Dosage:
- 2mg to 5mg per injection, administered 2–3x per week for 2–4 weeks
- Often followed by a break period (1–2 months) to allow for tissue regeneration
Administration:
- Intraperitoneal (IP) or Subcutaneous (SC) injection
- Typically cycled with periods of no dosing to allow cellular recovery
This is not a daily-use peptide, instead it is designed to be used in pulsed, short-term cycles to “clean house.”
FOX04-DRI vs Other Senolytics
| Feature | FOX04-DRI | Dasatinib + Quercetin | Fisetin |
|---|---|---|---|
| Selectivity | High (targets senescent cells) | Moderate | Moderate |
| Administration | Subcutaneous injection | Oral (drug + flavonoid) | Oral (flavonoid) |
| Half-Life | Short to moderate | Variable | Short |
| Human Data | Limited | Some | Moderate |
| Ideal Use | Peptide-based senolysis | Broad-spectrum senolytic | Anti-inflammatory support |
FOX04-DRI offers precise targeting with fewer systemic effects, though research is ongoing.
Safety Profile of FOX04
FOX04-DRI is still in early-stage research, and human clinical trials are limited. However, preclinical models (especially in mice) have demonstrated excellent tolerability.
Known Safety Insights:
- Selectively kills senescent cells only
- Does not harm healthy, non-senescent tissue
- No mutagenic or carcinogenic activity observed in studies to date
Possible Side Effects:
- Temporary fatigue or mild flu-like symptoms
- Inflammatory response after rapid cell clearance
- Mild soreness at injection site
References:
- Baar et al., “Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis.” Cell, 2017. https://pubmed.ncbi.nlm.nih.gov/28459435/
How to Store FOX04
- Store lyophilized FOX04-DRI at 2–8°C in a dark, dry environment
- Once reconstituted, refrigerate and use within 14–30 days
- Reconstitute with bacteriostatic water, avoid vigorous shaking
Stacking Considerations
FOX04-DRI can be part of advanced anti-aging or senolytic stacks:
- Rapamycin (research only) – for mTOR inhibition and longevity signaling
- GHK-Cu – to support skin healing and post-senolytic regeneration
- Epithalon – to promote telomerase activity and support circadian regulation
- BPC-157 – for systemic healing and inflammation control
Stacking should be done cautiously and based on research objectives.
Is FOX04-DRI Right for Your Research?
If your research focuses on cellular aging, senescence, or inflammation-driven degeneration, this peptide offers a cutting-edge tool. Its selective action on senescent cells opens new doors in longevity science and age-related disease modeling.
FOX04-DRI is best suited for cyclical protocols aimed at clearing damaged cells to promote younger, more functional tissues.
Final Thoughts
FOX04-DRI represents a new frontier in peptide-based anti-aging science. By removing what no longer serves the body, it helps pave the way for renewal and regeneration. For those studying longevity, cellular health, or post-injury recovery, FOX04-DRI deserves a central role in your peptide toolkit.
Lab of RAD is proud to offer research-grade FOX04-DRI for advanced cellular investigations.
⚠️ FDA Disclaimer
This information is for research and educational purposes only. FOX04-DRI has not been approved by the U.S. Food and Drug Administration (FDA) for human use. It is not intended to diagnose, treat, cure, or prevent any disease. Always consult a licensed professional before conducting any experimental protocol.
Lab of RAD peptides are sold for laboratory research use only and are not for human consumption.