GHRP-2
The Appetite-Enhancing Growth Hormone Secretagogue
What is GHRP-2?
GHRP-2, short for Growth Hormone Releasing Peptide-2, is a synthetic hexapeptide that powerfully stimulates endogenous growth hormone (GH) release. It acts as a ghrelin mimetic, binding to the GHS-R1a receptor in the pituitary and hypothalamus to trigger a strong, natural GH pulse.
GHRP-2 is often used in peptide research for its role in muscle development, fat loss, immune function, and recovery support. Compared to similar peptides like GHRP-6 and Ipamorelin, GHRP-2 produces a stronger GH response, with moderate appetite stimulation.
How Does GHRP-2 Work?
GHRP-2 works by mimicking the effects of ghrelin, a hormone that not only increases hunger but also activates the growth hormone secretagogue receptor (GHS-R). This receptor, found in the pituitary gland, triggers growth hormone release from somatotropic cells.
Mechanism of Action:
- Binds to GHS-R1a receptor in the brain and pituitary
- Stimulates GH release and subsequently increases IGF-1
- Enhances fat metabolism and lean mass preservation
- Improves deep sleep and cellular repair processes
GHRP-2 acts independently of GHRH, meaning it can be used solo or stacked for synergy.
Key Benefits of GHRP-2
💪 Muscle Growth & Recovery
- Increases growth hormone and IGF-1 levels
- Promotes protein synthesis and muscle repair
- Helps prevent muscle loss during calorie deficits
🔥 Fat Loss Support
- Enhances lipolysis (fat breakdown)
- Increases energy utilization from stored fat
- May improve body composition over time
😴 Sleep & Recovery
- Encourages deep sleep phases where GH release is highest
- Enhances tissue regeneration and immune modulation
🧠 Cognitive & Mood Support
- Indirect support of neurogenesis through IGF-1
- Potential improvements in mood and cognitive clarity
GHRP-2 vs Other GH Secretagogues
| Feature | GHRP-2 | GHRP-6 | Ipamorelin |
|---|---|---|---|
| GH Release | Strong | Strong | Moderate |
| Appetite Stimulation | Mild to moderate | High | Minimal |
| Prolactin/Cortisol Risk | Low to moderate | Moderate | Very low |
| Ideal For | GH boost + moderate hunger | Bulking/hunger stimulation | Clean GH release cycles |
GHRP-2 is a balanced choice for researchers seeking strong GH elevation with less appetite disruption than GHRP-6.
Suggested Dosage & Protocol
Common Dosing Guidelines:
- 100mcg to 300mcg per dose, 2–3 times daily
- Best injected subcutaneously (SC) or intramuscularly (IM)
- Cycle Length: 6–12 weeks for measurable effects
Optimal Timing:
- Morning (fasted)
- Post-workout
- 30–60 minutes before bedtime
To maximize GH release, avoid consuming food (especially carbs/fats) 60 minutes before and after injection.
GHRP-2 + Synergistic Stacks
GHRP-2 is highly synergistic with:
- CJC-1295 (without DAC) – for a strong GH surge with natural pulse rhythm
- BPC-157 – to enhance recovery and repair
- Epithalon or DSIP – for sleep optimization and anti-aging
- GHK-Cu – for collagen and skin regeneration
Stacks can be tailored to suit fat loss, anti-aging, or anabolic research goals.
Safety Profile of GHRP-2
GHRP-2 is generally well tolerated. However, since it stimulates pituitary hormone release, moderate elevations in cortisol and prolactin may occur at higher doses.
Commonly Reported Effects:
- Improved energy, mood, and sleep
- Mild hunger increase (less than GHRP-6)
- Warm flushing or lightheadedness post-injection (transient)
Rare Side Effects:
- Temporary water retention
- Slight tingling or numbness (due to elevated GH/IGF-1)
- Minor joint stiffness
Reference:
- Smith RG et al., “GHRP-2: A potent GH secretagogue that increases GH release in humans.” J Clin Endocrinol Metab, 1995. https://pubmed.ncbi.nlm.nih.gov/7536213/
How to Store GHRP-2
- Store lyophilized GHRP-2 in the refrigerator (2–8°C)
- After reconstitution, refrigerate and use within 14–30 days
- Reconstitute with bacteriostatic water
- Avoid excessive agitation and exposure to light
Is GHRP-2 Right for Your Research?
If your research focuses on growth hormone optimization, muscle retention, or tissue recovery, GHRP-2 delivers potent GH stimulation with excellent synergy options. Its balance of performance-enhancing and restorative properties makes it a staple in both clinical and biohacking research.
Final Thoughts
GHRP-2 is a highly effective GH-releasing peptide that bridges the gap between intensity and control. Whether you’re studying muscle growth, metabolic recovery, or healthy aging, GHRP-2 provides a reliable molecular tool to stimulate the body’s own growth hormone axis.
Lab of RAD offers research-grade GHRP-2 for advanced regenerative and performance science.
⚠️ FDA Disclaimer
This content is for research and educational purposes only. GHRP-2 has not been evaluated or approved by the U.S. Food and Drug Administration (FDA). It is not intended to diagnose, treat, cure, or prevent any disease. Always consult a licensed professional before conducting any research.
Lab of RAD peptides are intended for laboratory research use only and are not for human consumption.