hGH Fragment 176-191

Fat Loss Without the Side Effects of Growth Hormone

What is hGH Fragment 176-191?

hGH Fragment 176-191 is a modified version of the human growth hormone (hGH) molecule, specifically a peptide fragment comprising amino acids 176 through 191 of the full-length hGH sequence. This fragment retains the fat-burning and metabolic-enhancing properties of hGH, while removing the growth-promoting and blood sugar-altering effects.

Originally developed by researchers at Monash University, hGH Frag 176-191 is designed to stimulate lipolysis (fat breakdown) and inhibit lipogenesis (fat formation), making it a targeted tool for reducing stubborn adipose tissueā€”particularly visceral and abdominal fat.

Key Advantage: hGH Frag 176-191 delivers the benefits of hGH in fat metabolism without increasing IGF-1 levels or causing insulin resistance.

How It Works

Unlike full-length growth hormone, which affects a wide variety of systems (muscle, bone, organs, glucose metabolism), hGH Fragment 176-191 acts specifically on adipose tissue. It binds to the GH receptor in fat cells, triggering pathways that:

  • Activate hormone-sensitive lipase (HSL)
  • Stimulate beta-oxidation of fatty acids
  • Inhibit new fat cell formation
  • Enhance mitochondrial energy output

Importantly, it does not affect blood glucose, IGF-1, or carbohydrate metabolism, making it a safer option for long-term fat reduction strategies.

Source: Ng FM, et al. ā€œThe lipolytic actions of human growth hormone are mediated by the C-terminal region of the hGH molecule.ā€ J Endocrinol. 2000;167(2):317ā€“327.

Benefits of hGH Fragment 176-191

šŸ”„ Fat Loss (Especially Abdominal and Visceral)

  • Targets stubborn fat without affecting lean muscle
  • Effective in both men and women
  • May improve waist circumference and body composition

āš–ļø Improved Metabolic Profile

  • Enhances fat oxidation without altering glucose or insulin levels
  • Supports increased energy expenditure at rest and during exercise

šŸ§¬ Non-Anabolic, Targeted Action

  • No muscle growth, organ growth, or undesired cell proliferation
  • Safer than full hGH for those seeking only metabolic effects

šŸ›Œ May Improve Sleep and Recovery

  • Indirectly supports better sleep and recovery via metabolic regulation
  • Often used in fat loss stacks with peptides like CJC-1295, Ipamorelin, or AOD-9604

Use Cases

  • Individuals seeking fat loss without hormonal side effects
  • Those with insulin sensitivity issues or glucose management concerns
  • Athletes or physique competitors looking to cut body fat while preserving muscle
  • Aesthetic medicine protocols focused on body contouring and recomposition

Dosing and Administration

hGH Fragment 176-191 is typically administered via subcutaneous injection, ideally in the abdominal area or around fatty tissue.

Common Protocol:

  • Dose: 250ā€“500 mcg per injection
  • Frequency: 1ā€“2 times per day (morning and/or pre-bed, or pre-cardio)
  • Cycle Duration: 4ā€“12 weeks, with or without breaks

For best results, pair with a caloric deficit and mild exercise regimen.

Oral or transdermal versions exist but are generally less bioavailable than injections.

Stacking Compatibility

hGH Frag 176-191 is often stacked with:

  • AOD-9604 ā€“ synergistic fat-burning effect
  • Ipamorelin or CJC-1295 ā€“ GH pulse amplification
  • BPC-157 ā€“ injury recovery alongside fat loss
  • GLP-1 receptor agonists (e.g., Semaglutide, Tirzepatide) ā€“ appetite suppression and metabolic synergy

Safety and Side Effects

hGH Fragment 176-191 has a strong safety profile and does not share the risks associated with full-length growth hormone. It does not raise blood glucose, does not cause acromegaly, and does not elevate IGF-1.

Possible mild side effects may include:

  • Temporary injection site irritation
  • Mild water retention (rare)
  • Increased energy or thermogenesis

Reference: Heffernan M, et al. ā€œThe lipolytic effects of a human growth hormone fragment (hGH 176-191) in obese individuals.ā€ J Clin Endocrinol Metab. Unpublished data cited in patent AU2004203363.

Conclusion

hGH Fragment 176-191 is a precision-designed fat loss peptide, offering the metabolic advantages of growth hormone therapy without the systemic side effects. Whether you’re an athlete cutting for competition, someone managing metabolic challenges, or simply looking to target stubborn belly fat, this peptide may be your non-hormonal solution for optimized body composition.

For maximum benefit, integrate hGH Frag 176-191 into a comprehensive peptide protocol, guided by lifestyle, goals, and a supportive medical professional.