Ipamorelin
The Cleanest Growth Hormone Secretagogue for Recovery, Fat Loss, and Longevity
What is Ipamorelin?
Ipamorelin is a selective growth hormone secretagogue and ghrelin receptor agonist, developed to stimulate the body’s natural release of growth hormone (GH). Unlike earlier GHRPs (like GHRP-6 or GHRP-2), Ipamorelin offers precise GH release with minimal side effects, such as hunger, cortisol spikes, or prolactin elevation.
It is widely used in peptide research focused on anti-aging, fat loss, muscle preservation, and recovery support, making it a favorite among those seeking a clean, reliable tool for endocrine optimization.
How Does Ipamorelin Work?
Ipamorelin binds specifically to the GHS-R1a receptor (ghrelin receptor) in the pituitary and hypothalamus. This triggers pulsatile growth hormone release without significantly altering ACTH, cortisol, or prolactin levels.
Mechanism of Action:
- Stimulates GH secretion by activating GHS-R1a
- Does not stimulate appetite like other GHRPs
- Maintains natural GH pulsatility
- Promotes IGF-1 production downstream
Benefits of Ipamorelin
💪 Lean Muscle & Recovery
- Supports muscle preservation and growth
- Enhances tissue regeneration and injury recovery
- Often used in post-surgical and rehabilitation protocols
🔥 Fat Loss & Metabolic Health
- Stimulates lipolysis (fat breakdown)
- Encourages lean body composition
- Improves energy metabolism and recovery in caloric deficits
🧠 Cognitive & Sleep Support
- Enhances deep, restorative sleep
- May support neuroprotection and mood regulation
🧪 Precision & Tolerance
- Does not raise cortisol or prolactin levels
- Minimal to no appetite stimulation
- Well tolerated across all dosing tiers
Ipamorelin vs GHRP-2 vs GHRP-6
| Feature | Ipamorelin | GHRP-2 | GHRP-6 |
|---|---|---|---|
| GH Release Strength | Moderate | Strong | Strong |
| Appetite Stimulation | None to Minimal | Mild to Moderate | High |
| Cortisol/Prolactin | None | Low to Moderate | Moderate |
| Best Use Case | Anti-aging, clean recovery | Recomp, moderate fat loss | Bulking, appetite support |
Ipamorelin is ideal for precision GH cycling without unwanted hormonal disruption.
Suggested Dosage & Protocol
Common Dosage:
- 100mcg to 300mcg, 1–3x per day, based on goals
- Administer via subcutaneous (SC) or intramuscular (IM) injection
Timing:
- Morning (fasted)
- Post-workout
- Pre-bedtime to enhance overnight GH release
Cycle Duration:
- Typical cycles last 6–12 weeks
- Can be stacked or cycled with other GH secretagogues
Ideal Stack Partners
Ipamorelin pairs well with:
- CJC-1295 (no DAC) – to synchronize GH pulses with GHRH action
- BPC-157 or TB-500 – for enhanced healing and recovery
- GHK-Cu – for skin and collagen regeneration
- Epithalon – for anti-aging and circadian optimization
Safety Profile of Ipamorelin
Ipamorelin is one of the safest GH secretagogues available and has been widely studied for its clean hormonal profile.
Known Safety Insights:
- No significant increase in cortisol, prolactin, or ACTH
- No appetite spikes
- No reported increase in insulin resistance
Possible Side Effects (rare):
- Mild injection site irritation
- Transient flushing or dizziness
- Temporary fatigue in some individuals
Reference:
- Raun K. et al., “Ipamorelin, a new growth-hormone-releasing peptide, induces growth hormone release in humans.” European Journal of Endocrinology, 1998. https://pubmed.ncbi.nlm.nih.gov/9558747/
Storage Instructions
- Store lyophilized Ipamorelin at 2–8°C (refrigerated)
- After reconstitution, refrigerate and use within 14–30 days
- Reconstitute with bacteriostatic water
Is Ipamorelin Right for Your Research?
If your research focuses on growth hormone modulation, body composition, or recovery, Ipamorelin is a low-risk, high-precision candidate. It’s especially useful in protocols requiring clean hormonal signaling without confounding appetite or cortisol effects.
Final Thoughts
Ipamorelin delivers reliable, controlled GH release with minimal side effects—making it one of the most user-friendly and clinically valuable secretagogues in peptide research. Whether used alone or stacked, it remains a go-to for muscle recovery, anti-aging, and fat metabolism protocols.
Lab of RAD offers research-grade Ipamorelin in various sizes to meet your advanced protocol needs.
⚠️ FDA Disclaimer
This page is intended for educational and research purposes only. Ipamorelin has not been evaluated or approved by the U.S. Food and Drug Administration (FDA). It is not intended to diagnose, treat, cure, or prevent any disease.
Lab of RAD peptides are sold for laboratory research use only and are not for human consumption.