KPV

Precision Anti-Inflammatory Power for Gut, Skin, and Beyond

What is KPV?

KPV is a tripeptide fragment (Lysine–Proline–Valine) derived from the C-terminal end of alpha-melanocyte-stimulating hormone (α-MSH). Unlike the full α-MSH molecule, which has broader endocrine and pigmentation effects, KPV selectively exhibits potent anti-inflammatory and immunomodulatory activity—without influencing melanin production.

This makes KPV a key focus in peptide research targeting inflammation, skin disorders, gut health, and immune modulation.

How Does KPV Work?

KPV acts by binding to melanocortin receptors, primarily MC1R, which are expressed in immune and epithelial cells. This receptor interaction suppresses the production of pro-inflammatory cytokines and NF-κB activity, reducing inflammation systemically and locally.

Mechanism of Action:

  • Inhibits NF-κB signaling, a master regulator of inflammation
  • Downregulates TNF-α, IL-1β, IL-6, and IFN-γ
  • Modulates macrophage and epithelial cell activity
  • Supports gut barrier integrity and immune homeostasis

Benefits of KPV

🔥 Anti-Inflammatory Activity

  • Suppresses excessive cytokine production
  • Helps control chronic inflammatory states (e.g., autoimmune conditions)
  • Topical and injectable forms both show systemic benefits

🧫 Gut & Immune Health

  • Supports gut epithelial repair and tight junction integrity
  • May reduce symptoms of IBD, colitis, and leaky gut syndrome
  • Balances innate and adaptive immune responses

🧴 Dermatological Support

  • Reduces inflammation in eczema, psoriasis, and acne
  • May be used topically or subcutaneously for targeted relief
  • Promotes skin healing and reduced hyperreactivity

🧠 Neuroimmune Modulation

  • May help lower neuroinflammation in models of brain injury
  • Supports systemic inflammation balance in autoimmune protocols

Suggested Dosage & Protocol

KPV can be administered both topically and systemically depending on the research goal.

Typical Dosage:

  • 100mcg to 500mcg per day, divided into 1–2 doses
  • Administered subcutaneously (SC) or topically

Timing:

  • Can be dosed morning and/or evening depending on symptom severity
  • Used daily or in cycles of 2–4 weeks for inflammation-focused protocols

KPV vs BPC-157 vs TB-500

FeatureKPVBPC-157TB-500
Anti-InflammatoryStrongStrongModerate
GI RepairExcellentExcellentMild
Skin HealingExcellent (topical)ModerateModerate
Immune ModulationHighModerateLow
Hormonal ActivityNoneNoneMild (via actin pathway)

KPV offers the most targeted immune modulation with minimal risk of off-target activity.

Safety Profile of KPV

KPV is well tolerated and poses minimal systemic side effects, thanks to its selectivity and short half-life. It is non-immunogenic and does not cross-react with hormonal pathways.

Safety Insights:

  • Does not affect pigmentation or endocrine function
  • No known pro-inflammatory rebound effects
  • Safe for repeated topical or injectable use

Rare Side Effects:

  • Mild skin irritation (topical use)
  • Minor injection site redness (SC)
  • Very rare reports of transient headache or fatigue

Reference:

Storage Instructions

  • Store lyophilized KPV at 2–8°C in a dry, dark environment
  • After reconstitution with bacteriostatic water, refrigerate and use within 14–30 days
  • Avoid excessive light, heat, or agitation

Stack Recommendations

KPV is commonly stacked with:

  • BPC-157 – for full-spectrum gut and soft tissue repair
  • GHK-Cu – for skin regeneration and cosmetic protocols
  • ARA-290 – for neuropathic and immune-related inflammation
  • Thymosin Alpha-1 – for immune and anti-infective synergy

Is KPV Right for Your Research?

If you’re investigating chronic inflammation, autoimmune response, gut repair, or skin healing, KPV is a precise, non-hormonal anti-inflammatory agent. Its broad utility and safety profile make it a valuable asset in both acute and long-term studies.

Final Thoughts

KPV offers a targeted, science-backed approach to inflammation control, without disrupting natural hormones or creating dependency. It excels in gut health, dermatology, immune balance, and systemic recovery—all in a clean, minimalist tripeptide format.

Lab of RAD is proud to offer high-purity KPV peptide for advanced inflammation and immune modulation research.

⚠️ FDA Disclaimer

This page is intended for research and educational purposes only. KPV has not been evaluated or approved by the U.S. Food and Drug Administration (FDA). It is not intended to diagnose, treat, cure, or prevent any disease.

Lab of RAD peptides are for laboratory research use only and are not for human consumption.