Melanotan 1 (MT-1)
Sunless Tanning and Photoprotection with Precision
What is Melanotan-1 (MT-1)?
Melanotan-1, also known as Afamelanotide, is a synthetic analog of alpha-melanocyte-stimulating hormone (α-MSH). It is primarily studied for its ability to stimulate melanin production in the skin by acting on the melanocortin-1 receptor (MC1R). MT-1 promotes UV-independent tanning, offering a photoprotective effect without the DNA-damaging effects of direct sun exposure.
Originally developed as a treatment for skin disorders like erythropoietic protoporphyria (EPP), MT-1 has also gained interest in research related to skin pigmentation, sun protection, and oxidative stress mitigation.
How Does MT-1 Work?
MT-1 mimics the action of natural α-MSH by binding to the MC1R receptor on melanocytes, the pigment-producing cells in the skin. This stimulates melanin synthesis, resulting in a deeper and more sustained tan, even with minimal UV exposure.
Mechanism of Action:
- Binds to melanocortin-1 receptor (MC1R)
- Stimulates eumelanin (dark pigment) production
- Enhances UV resistance by increasing melanin concentration in skin
- Provides antioxidant and anti-inflammatory benefits
Benefits of Melanotan-1
☀️ UV-Free Tanning
- Encourages natural-looking pigmentation without excess sun
- Darkens skin tone gradually and evenly
- Ideal for fair-skinned individuals or those with UV sensitivity
🛡️ Skin Protection
- Enhances the skin’s natural photoprotection
- Reduces risk of UV-induced DNA damage
- May help prevent sunburn and reduce photoaging
💊 Additional Research Areas
- Shows anti-inflammatory effects in skin and systemic conditions
- Studied for roles in appetite control and energy metabolism (via MC receptors)
- Potential mood and libido effects under broader melanocortin pathway studies
MT-1 vs MT-2 vs Natural α-MSH
| Feature | Melanotan-1 (MT-1) | Melanotan-2 (MT-2) | Natural α-MSH |
|---|---|---|---|
| Pigmentation Effect | Strong and selective | Strong but less selective | Moderate |
| Receptor Specificity | High for MC1R | Binds MC3R/MC4R/MC5R also | High for MC1R |
| Side Effects | Minimal | Possible nausea, flushing | None |
| Sexual Function Impact | None | Increased libido reported | None |
| Application Focus | Skin tanning, EPP | Libido + tanning | Endogenous melanogenesis |
MT-1 is preferred when tanning and photoprotection are the primary research goals.
Suggested Dosage & Protocol
Research Dosing Guidelines:
- 250mcg to 1mg per day, via subcutaneous (SC) injection
- Initial loading period: 5–10 days
- Maintenance dosing: 2–3x per week as needed
Timing:
- Administer in the evening to minimize photosensitivity
- Minimal UV exposure (5–15 mins) may enhance pigmentation response
Duration:
- Initial phase: 2–3 weeks to achieve baseline pigmentation
- Maintenance: varies depending on individual response and study goals
Safety Profile of Melanotan-1
MT-1 is generally well tolerated with a favorable safety record, particularly in comparison to MT-2.
Commonly Reported Effects:
- Mild skin flushing or redness (transient)
- Darkening of existing moles or freckles (monitoring recommended)
- Fatigue or slight appetite suppression in rare cases
Rare Effects:
- Injection site irritation
- Mild nausea at higher doses
Reference:
- Thompson, C. et al., “Afamelanotide for Erythropoietic Protoporphyria.” NEJM, 2015. https://pubmed.ncbi.nlm.nih.gov/26352800/
Storage Instructions
- Store lyophilized MT-1 at 2–8°C
- Reconstitute with bacteriostatic water
- Refrigerate after reconstitution and use within 14–30 days
Stack Recommendations
Melanotan-1 can be paired with:
- GHK-Cu – for skin rejuvenation and collagen support
- NAD+ or Glutathione – for antioxidant and skin detox synergy
- Topical peptides – to enhance pigmentation at specific sites
Is Melanotan-1 Right for Your Research?
If your research targets melanin synthesis, photoprotection, or skin pigmentation disorders, Melanotan-1 provides a highly selective and clinically studied option. It delivers tanning and skin protective effects without the broader receptor activity seen in other analogs.
Final Thoughts
Melanotan-1 offers a clean, targeted pathway to pigmentation and sun protection, ideal for clinical and cosmetic studies. Its selectivity, safety, and photoprotective effects make it a staple in UV-independent melanogenesis research.
Lab of RAD offers research-grade Melanotan-1 in multiple concentrations to support advanced dermatological and endocrine studies.
⚠️ FDA Disclaimer
This information is for educational and research purposes only. Melanotan-1 has not been evaluated or approved by the U.S. Food and Drug Administration (FDA). It is not intended to diagnose, treat, cure, or prevent any disease.
Lab of RAD peptides are sold for laboratory research use only and are not for human consumption.