Melanotan 2 (MT-2)
The Multifunctional Peptide for Tanning, Libido, and Vitality
What is Melanotan-2?
Melanotan-2 (MT-2) is a synthetic analog of alpha-melanocyte-stimulating hormone (α-MSH) designed to activate multiple melanocortin receptors (MC1R, MC3R, MC4R, MC5R). It is primarily studied for its ability to stimulate melanin production, enhance libido, and regulate appetite and energy balance.
MT-2 is well known in peptide research for its dual action on skin pigmentation and sexual function, making it one of the most versatile melanocortin peptides studied today.
How Does MT-2 Work?
MT-2 works by binding to several melanocortin receptors:
- MC1R: Promotes melanin synthesis and skin pigmentation
- MC3R / MC4R: Modulates sexual behavior, appetite, and energy homeostasis
- MC5R: Involved in exocrine gland regulation
Mechanism of Action:
- Stimulates melanogenesis in melanocytes (UV-independent tanning)
- Triggers erectogenic responses through MC4R stimulation
- Modulates central appetite and mood pathways
Benefits of Melanotan-2
☀️ Skin Pigmentation
- Stimulates UV-independent melanin production
- Darkens skin naturally and evenly with minimal sun exposure
- Offers photoprotective effects against UV-induced DNA damage
❤️ Sexual Health & Libido
- Enhances sexual desire and arousal
- Supports erectile function in males via MC4R pathway
- May improve sexual confidence and frequency in both sexes
🍽️ Appetite & Weight Regulation
- May reduce appetite and food intake via central melanocortin pathways
- Promotes leaner body composition in animal models
MT-2 vs MT-1 vs PT-141
| Feature | MT-2 | MT-1 | PT-141 |
|---|---|---|---|
| Pigmentation Effect | Strong | Strong & Selective | None |
| Libido Enhancement | Strong | None | Strong |
| Appetite Modulation | Mild to Moderate | None | Mild |
| Target Receptors | MC1R–MC5R | Primarily MC1R | Primarily MC4R |
| Ideal Use | Tanning + Libido + Energy | Tanning + Photoprotection | Libido/FSD/ED research |
MT-2 is the most multifunctional of the melanocortin peptides, offering benefits across skin, sex, and appetite.
Suggested Dosage & Protocol
Common Research Dosage:
- 250mcg to 1mg per dose, via subcutaneous (SC) injection
- Start with a low dose to assess tolerance due to common side effects
Dosing Strategy:
- Loading Phase: Daily or every other day for 10–14 days
- Maintenance: 2–3 doses per week, or as needed
Timing:
- Dose in the evening to minimize nausea
- Pair with light UV exposure (5–10 mins) for optimal melanin response
Safety Profile of MT-2
MT-2 is potent and multifunctional, but more prone to side effects than MT-1 or PT-141. Start with low dosing to build tolerance.
Common Side Effects:
- Nausea, especially early in treatment
- Facial flushing, mild warmth
- Increased sexual arousal and spontaneous erections (males)
- Darkening of moles/freckles (monitor for abnormal changes)
Rare Effects:
- Decreased appetite
- Headaches or mild fatigue
- Hyperpigmentation in unintended areas
Reference:
- Hadley ME et al., “Melanocortin peptides for tanning and sexual function.” Ann NY Acad Sci, 2003. https://pubmed.ncbi.nlm.nih.gov/14964341/
Storage Instructions
- Store lyophilized MT-2 at 2–8°C
- Reconstitute with bacteriostatic water
- Use reconstituted product within 14–30 days, kept refrigerated
Stack Recommendations
MT-2 can be integrated into various research protocols:
- GHK-Cu – to support skin renewal and pigmentation balance
- PT-141 – for advanced sexual function research
- NAD+ or Glutathione – to balance oxidative stress from UV exposure
Is MT-2 Right for Your Research?
If your research focuses on tanning, libido enhancement, or metabolic regulation, Melanotan-2 offers a highly potent and multi-target solution. It’s especially useful in studies involving melanin production and sexual arousal pathways.
Final Thoughts
Melanotan-2 is a uniquely versatile peptide, bridging research into dermatology, endocrinology, and sexual health. Its multifunctionality makes it a compelling tool in advanced peptide-based studies—but one that should be used with care and precise dosing.
Lab of RAD offers high-purity Melanotan-2 (MT-2) for research teams pushing the boundaries of melanocortin science.
⚠️ FDA Disclaimer
This content is for educational and research purposes only. Melanotan-2 has not been evaluated or approved by the U.S. Food and Drug Administration (FDA). It is not intended to diagnose, treat, cure, or prevent any disease.
Lab of RAD peptides are for laboratory research use only and are not for human consumption.