Melanotan 2 (MT-2)

The Multifunctional Peptide for Tanning, Libido, and Vitality

What is Melanotan 2?

Melanotan 2 (MT-2) is a synthetic analog of alpha-melanocyte-stimulating hormone (α-MSH) that stimulates melanocortin receptors in the body. Originally developed as a sunless tanning agent, MT-2 is now widely known for its dual effects—promoting a deep, natural tan and enhancing libido.

MT-2 binds to multiple melanocortin receptors, including MC1R (skin pigmentation) and MC3R/MC4R (sexual function and appetite regulation), giving it a broader range of physiological effects than its more selective cousin Melanotan 1 (MT-1).

Key Mechanism: MT-2 stimulates melanin production and activates sexual arousal pathways in the brain, making it one of the few peptides with both cosmetic and libido-enhancing effects.

Core Benefits of Melanotan 2

🌞 Sunless Tanning

• Deepens pigmentation without the need for extended UV exposure
• Helps fair-skinned individuals tan more easily and safely
• Reduces risk of sunburn and UV-induced skin damage

❤️ Enhanced Libido and Sexual Arousal

• Strongly activates MC4R receptors associated with sexual desire and arousal
• Especially notable in men with erectile dysfunction (ED) or low libido
• May increase sexual sensitivity and spontaneity in both men and women

🧬 Photoprotection and Skin Support

• Increases eumelanin (dark pigment) to protect skin from UV-induced DNA damage
• May reduce risk of long-term sun-related aging and damage

🧠 Mood and Energy Boost (Anecdotal)

• Some users report elevated mood, increased confidence, and higher energy
• May support circadian rhythm through hypothalamic receptor interaction

Reference: Hadley ME, et al. “Melanocortin peptides and their receptors: from melanocytes to appetite regulation and beyond.” Peptides. 2006;27(2):273–298.

Melanotan 2 vs. Melanotan 1

Mechanism of Action

MT-2 mimics the action of α-MSH by binding to melanocortin receptors throughout the body. This results in:

• Melanin production (via MC1R in melanocytes)
• Sexual arousal (via MC4R in the brain and spinal cord)
• Energy metabolism and appetite modulation (via MC3R/MC4R)

This broad receptor activation makes MT-2 a multi-effect peptide, with overlapping cosmetic, neurological, and endocrine outcomes.

Dosing and Administration

MT-2 is typically administered subcutaneously, and dosing is titrated to minimize side effects like nausea or flushing.

Typical Dosing Protocol (Experimental Use):

• Loading Phase:
  – 100–250 mcg daily
  – Increase gradually up to 500–1000 mcg as tolerated
  – Light sun exposure recommended to stimulate melanin activity
• Maintenance Phase:
  – 500 mcg 1–2x per week
  – Tanning effect typically lasts weeks after stopping

Note: UV exposure enhances tanning results. MT-2 does not produce melanin without minimal UV stimulation.

Safety and Side Effects

MT-2 is generally well tolerated, but its non-selective receptor activity means it has more potential for temporary side effects than MT-1.

Common Side Effects:

• Nausea (most common; dose-dependent, often transient)
• Facial flushing or warmth
• Appetite suppression
• Freckle/dark mole darkening
• Increased sexual arousal (can be spontaneous or pronounced)
• Erections unrelated to sexual activity (men)

Rare or cautious concerns:

• Hyperpigmentation in individuals with uneven melanin distribution
• Avoid use in individuals with a history of melanoma or pigmented lesion changes without medical supervision

Reference: Wessells H, et al. “Melanotan-II and erectile response in men with erectile dysfunction.” Int J Impot Res. 2000;12(Suppl 4):S74–S79.

Storage and Stability

• Store reconstituted MT-2 in the refrigerator
• Use within 30 days of mixing
• Protect from light and contamination

Conclusion

Melanotan 2 is a powerful, dual-purpose peptide known for its rapid tanning effects and robust libido enhancement. Whether used for cosmetic tanning, sexual health, or both, MT-2 offers a versatile option for performance and appearance optimization—especially for individuals seeking sunless tanning with extra vitality benefits.

Its broad receptor activity, however, means that it must be used with careful dosing and monitoring, especially for new users. When respected and understood, MT-2 remains one of the most popular cosmetic and vitality-enhancing peptides in the world.