Pinealon

The Tripeptide for Cognitive Longevity, Brain Repair, and Cellular Rejuvenation

What is Pinealon?

Pinealon is a synthetic short-chain peptide composed of three amino acids: Glutamic acid, Aspartic acid, and Arginine (Glu-Asp-Arg). It belongs to the class of Khavinson peptides, developed by Russian gerontologists to regulate gene expression and support healthy aging. Pinealon has been shown to exert nootropic, neuroprotective, and geroprotective effects, particularly in models of cognitive decline, ischemic injury, and neurodegeneration.

Unlike traditional nootropics that act on neurotransmitter levels, Pinealon modulates gene transcription, mitochondrial function, and protein synthesis, making it a compelling peptide for brain aging, oxidative stress, and mental fatigue research.

How Does Pinealon Work?

Pinealon acts at the cellular and epigenetic level, supporting neurogenesis and neuronal repair by modulating gene expression. It influences DNA and RNA synthesis, boosts mitochondrial protein synthesis, and helps regulate redox balance and cellular energy metabolism.

Mechanism of Action:

  • Modulates expression of genes related to brain development and neuroplasticity
  • Increases RNA polymerase activity, boosting protein synthesis
  • Enhances mitochondrial respiration and ATP production
  • Reduces reactive oxygen species (ROS) and lipid peroxidation in neurons
  • Preserves neuronal cell membrane integrity under oxidative stress

Benefits of Pinealon

🧠 Cognitive Enhancement

  • Improves short-term memory, focus, and cognitive stamina
  • Reduces mental fatigue and brain fog, particularly under stress
  • Supports executive function and learning speed in older adults

🛡️ Neuroprotection & Anti-Aging

  • Prevents neuronal apoptosis from oxidative damage or ischemia
  • Enhances brain resilience in aging and neurodegenerative models
  • Delays progression of age-related cognitive decline

🧬 Epigenetic & Mitochondrial Support

  • Promotes healthy gene expression patterns in neural tissue
  • Enhances cellular energy metabolism via mitochondrial upregulation
  • Reduces inflammatory and oxidative burden on the brain

Pinealon vs Epithalon vs P21

FeaturePinealonEpithalonP21
Primary MechanismEpigenetic modulationTelomerase activationNeuroregeneration
Mitochondrial SupportStrongModerateModerate
Cognitive PerformanceStrongMildStrong
NeuroprotectionStrongModerateStrong
Ideal UseBrain aging, fatigueLongevity, aging systemCognitive repair

Pinealon is a focused brain-optimizing peptide with both acute and long-term benefits.

Suggested Dosage & Protocol

Common Research Dose:

  • 100mcg to 300mcg per day, administered via subcutaneous (SC) injection
  • May also be compounded for intranasal delivery (less common)

Cycle Duration:

  • Standard protocol: 10–20 days continuous use
  • Can be repeated every 1–3 months as needed

Timing:

  • Best taken in the morning or midday to support cognitive performance and mitochondrial activity

Safety Profile of Pinealon

Pinealon has been extensively researched in Russia and Eastern Europe with excellent tolerability and no known toxicity.

Observed Outcomes:

  • Enhanced alertness and cognitive function
  • Reduced fatigue and emotional lability
  • Safe for elderly and cognitive-impaired populations

Potential Side Effects:

  • Rare and mild, typically limited to injection site irritation
  • No known hormonal disruption, sedation, or withdrawal effects

Reference:

Storage Instructions

  • Store lyophilized Pinealon at 2–8°C in a cool, dry environment
  • Reconstitute with bacteriostatic water for injection
  • Use within 14–30 days of reconstitution; refrigerate between uses

Ideal Stack Recommendations

Pinealon can be synergistically combined with:

  • Epithalon – for full-body anti-aging and circadian regulation
  • P21 – for advanced neuroregenerative support
  • NAD+ or MOTS-c – for mitochondrial performance enhancement
  • N-Acetyl Semax Amidate – for cognitive and mood synergy

Is Pinealon Right for Your Research?

If your research investigates cognitive aging, mitochondrial decline, or neurodegeneration, Pinealon offers a powerful, non-stimulant approach to improving mental resilience and cellular repair. It is especially suitable for protocols focused on fatigue, oxidative damage, and long-term cognitive health.

Final Thoughts

Pinealon stands as a versatile and targeted peptide for brain and mitochondrial research. Whether your goals involve mental clarity, neuroprotection, or age-related cognition, Pinealon provides a well-tolerated, science-backed solution for high-level neural support.

Lab of RAD offers high-purity Pinealon for advanced cognitive and neuroprotective research applications.

⚠️ FDA Disclaimer

This information is intended for educational and research purposes only. Pinealon has not been evaluated or approved by the U.S. Food and Drug Administration (FDA). It is not intended to diagnose, treat, cure, or prevent any disease.

Lab of RAD peptides are sold for laboratory research use only and are not for human consumption.