Selank

The Anti-Anxiety Nootropic Peptide for Calm Focus and Mental Clarity

What is Selank?

Selank is a synthetic heptapeptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro) originally developed by the Institute of Molecular Genetics in Russia. It is derived from tuftsin, a naturally occurring immune-modulating peptide, and is designed to provide anxiolytic (anti-anxiety) and cognitive-enhancing effects — without sedation, dependency, or withdrawal symptoms.

Selank has been used in Russia as a prescription medication for anxiety and cognitive disorders and is increasingly popular worldwide in nootropic and biohacking circles due to its calming, focus-enhancing, and neuroprotective properties.

Key Benefit: Selank promotes mental clarity, calm, and resilience under stress, while improving memory and learning — all without affecting motor function or causing drowsiness.

How Selank Works

Selank modulates the brain’s neurochemical environment, particularly through its effects on:

  • GABAergic transmission — Enhancing GABA receptor activity (calm and anti-anxiety effect)
  • Serotonin metabolism — Supports emotional balance
  • BDNF expression — Encourages synaptic plasticity and brain repair
  • Immune system balance — Modulates cytokine response to reduce stress-related immune dysfunction

Unlike traditional benzodiazepines, Selank does not impair cognition, sedate, or lead to addiction — making it a safer and more sustainable option for long-term mood and brain support.

Reference: Andreeva LA, et al. “Anxiolytic and nootropic activity of Selank in rats exposed to chronic stress.” Neurosci Behav Physiol. 2010;40(5):531–538.

Key Benefits of Selank

😌 Anxiety and Stress Reduction

  • Reduces symptoms of generalized anxiety, tension, and worry
  • Calms the nervous system without dulling mental sharpness
  • Especially effective for social anxiety, performance stress, and burnout

🧠 Cognitive Enhancement

  • Improves concentration, memory formation, and mental stamina
  • Enhances verbal fluency, working memory, and attention span
  • Ideal for high-stress tasks requiring calm focus

🧬 Neuroprotection and Recovery

  • Increases brain-derived neurotrophic factor (BDNF)
  • Protects against cognitive decline and stress-induced brain damage
  • May be beneficial in TBI, neurodegeneration, or sleep deprivation

🛡️ Immune Modulation

  • Balances immune response during chronic stress
  • Inhibits overproduction of inflammatory cytokines
  • May assist in recovery from chronic fatigue or immune dysregulation

Use Cases for Selank

  • High-performance professionals seeking calm concentration
  • Individuals with mild to moderate anxiety
  • Students during exam preparation or academic stress
  • Those recovering from stress-related burnout
  • Adjunct for PTSD, ADHD, or mood stabilization protocols

Dosing and Administration

Selank is most commonly administered via intranasal spray, but subcutaneous injection is also used in research settings.

🔹 Intranasal Protocol (Typical Use):

  • Dose: 250–500 mcg per spray
  • Frequency: 1–2 sprays per nostril, 1–3x daily
  • Duration: Use as needed or in 5–10 day cycles

🔹 Subcutaneous (Research Use):

  • Dose: 250–750 mcg SC per day
  • Duration: 7–14 days per cognitive or mood-enhancement cycle

Can be stacked with Semax, N-Acetyl Selank Amidate, or PE-22-28 for enhanced nootropic or emotional support effects.

Safety and Side Effects

Selank is widely regarded as safe, non-toxic, and well-tolerated — even at higher doses or with long-term use.

Reported benefits:

  • Feeling “mentally grounded”
  • Reduction in overthinking or racing thoughts
  • Smooth and sustained focus without jitteriness

Rare or mild side effects:

  • Temporary nasal irritation
  • Vivid dreams or increased REM sleep
  • Slight fatigue in very sensitive users

Selank has no sedative, habit-forming, or withdrawal properties, making it ideal for regular or occasional use.

Reference: Ashmarin IP, et al. “Tuftsin and its analogs: immune and neuro-modulating activity.” Biochemistry (Moscow). 2005;70(3):300–305.

Conclusion

Selank is a neuroscience-informed, biologically intelligent solution for stress, anxiety, and mental fatigue. Whether you’re seeking peak performance under pressure, a calm yet alert state of mind, or a neuroprotective agent to safeguard cognitive health, Selank delivers profound results without compromise.

Backed by clinical research and real-world use, Selank is a cornerstone peptide for emotional resilience, cognitive clarity, and balanced neurochemistry — no pills, no fog, just calm control.