Selank
The Anti-Anxiety Nootropic Peptide for Calm Focus and Mental Clarity
What is Selank?
Selank is a synthetic heptapeptide derived from tuftsin, a naturally occurring immunomodulatory peptide found in immunoglobulin G (IgG). Developed by Russian scientists for use in anxiety, stress, and cognitive disorders, it has become one of the most well-researched nootropic and anxiolytic peptides in clinical and research settings.
Unlike its modified counterpart (N-Acetyl Selank Amidate), this version is the standard, unmodified form. It is highly effective for acute anxiety, chronic stress, cognitive fatigue, and immune balancing—all without causing sedation or dependency.
How Does Selank Work?
Selank influences neurotransmitter balance, immune modulation, and cognitive processing through several synergistic pathways.
Mechanism of Action:
- Enhances GABAergic signaling, producing calming effects without sedation
- Modulates levels of serotonin and dopamine
- Increases expression of BDNF (brain-derived neurotrophic factor)
- Regulates immune system cytokine profiles
- Influences gene expression tied to stress resilience and neuroplasticity
Benefits of Selank
😌 Anxiolytic Without Sedation
- Reduces generalized anxiety and social anxiety symptoms
- Promotes emotional stability without drowsiness
- Useful in protocols addressing PTSD, depression, and ADHD
🧠 Cognitive Performance & Focus
- Improves attention span, mental clarity, and processing speed
- Aids in memory consolidation and information recall
- May improve learning efficiency under stress
🛡️ Immune Modulation & Stress Response
- Balances immune hyperreactivity in inflammatory conditions
- Supports immune strength during physical or emotional stress
- Promotes anti-fatigue and adaptogenic effects
Selank vs N-Acetyl Selank Amidate vs Semax
| Feature | Selank | N-Acetyl Selank Amidate | Semax |
|---|---|---|---|
| Half-life | Short | Extended | Moderate |
| CNS Penetration | Moderate | High | High |
| Mood Stabilization | Strong | Stronger | Mild |
| Cognitive Support | Moderate–Strong | Strong | Strong |
| Dosing Frequency | 2–3x daily | 1–2x daily | 1–2x daily |
Selank offers fast-acting anxiolytic effects, while the N-Acetyl Amidate version is optimized for longer CNS action and neurotrophic synergy.
Suggested Dosage & Protocol
Intranasal Administration:
- 250mcg to 500mcg per dose, 2–3 times daily
- Onset occurs within 15–30 minutes with a duration of up to 3–5 hours
Subcutaneous Injection (less common):
- 100–300mcg, once or twice daily
- Best used in short-duration cycles of 2–4 weeks
Safety Profile of Selank
Selank has been used in clinical trials and medical practice in Russia with an excellent safety profile and no addictive potential.
Common Observations:
- Calm, relaxed, but alert mental state
- Improved mood, lower emotional reactivity
- Effective under acute or chronic stress models
Rare Side Effects:
- Nasal irritation with intranasal delivery
- Transient headache or mild dizziness
Reference:
- Andreeva LA et al., “Selank: anxiolytic and nootropic peptide with immunomodulatory properties.” Neurosci Behav Physiol, 2012. https://pubmed.ncbi.nlm.nih.gov/18577961/
Storage Instructions
- Store lyophilized Selank at 2–8°C
- Reconstitute with bacteriostatic water or sterile saline
- Refrigerate after reconstitution; use within 14–30 days
Ideal Stack Pairings
Selank pairs well with:
- Semax – for cognitive enhancement and neuroprotection
- DSIP – for anxiety + sleep cycle regulation
- Oxytocin – for emotional connection and social stress reduction
- P21 – for neuroplasticity and post-stress brain repair
Is Selank Right for Your Research?
If you’re researching non-sedating anxiolytics, neuroimmune interactions, or cognitive resilience, Selank is a valuable compound. Its calming yet alerting effects make it well-suited for behavioral science, neuropsychiatry, and nootropic protocols.
Final Thoughts
Selank is a clinically studied, multifunctional peptide that combines mental clarity with stress resilience. As a fast-acting anxiolytic with no risk of dependence, it’s a standout compound in the field of peptide-driven cognitive modulation.
Lab of RAD provides research-grade Selank for applications in stress adaptation, focus enhancement, and immune regulation.
⚠️ FDA Disclaimer
This information is provided for educational and research purposes only. Selank has not been evaluated or approved by the U.S. Food and Drug Administration (FDA). It is not intended to diagnose, treat, cure, or prevent any disease.
Lab of RAD peptides are sold for laboratory research use only and are not for human consumption.