Semax
The Neuroperformance Peptide for Focus, Repair, and Cognitive Resilience
What is Semax?
Semax is a synthetic peptide derived from a short segment of the adrenocorticotropic hormone (ACTH(4-10)), developed in Russia for use as a neuroprotective, nootropic, and neurorestorative agent. It has been studied extensively in both animal models and clinical settings for its ability to improve memory, learning, focus, stress resilience, and neural recovery—without affecting cortisol or adrenal hormone levels.
Unlike its modified counterpart (N-Acetyl Semax Amidate), this is the standard form of Semax, known for its fast-acting cognitive and neuroprotective effects with a well-established safety profile.
How Does Semax Work?
Semax exerts its benefits by modulating neurotransmitter systems, promoting neurotrophic factors, and enhancing blood flow to brain tissues.
Mechanism of Action:
- Increases expression of BDNF (brain-derived neurotrophic factor)
- Modulates dopamine, serotonin, and glutamate signaling
- Enhances cerebral blood flow and oxygen delivery
- Regulates gene expression related to neuroplasticity and repair
- Exhibits anti-inflammatory and antioxidant effects in the brain
Benefits of Semax
🧠 Cognitive Enhancement
- Improves memory consolidation, learning speed, and mental clarity
- Increases sustained attention and executive function
- May enhance academic or professional performance under pressure
⚡ Mental Stamina & Focus
- Reduces cognitive fatigue and supports mental endurance
- Enhances working memory in stressful or low-sleep environments
🛡️ Neuroprotection & Recovery
- Aids in recovery from ischemic events, head trauma, or neurological decline
- Promotes neuroregeneration and synaptic plasticity
- Can support post-illness cognitive restoration
Semax vs N-Acetyl Semax Amidate vs Selank
| Feature | Semax | N-Acetyl Semax Amidate | Selank |
|---|---|---|---|
| Duration of Action | Moderate (2–4 hrs) | Extended (4–8 hrs) | Moderate |
| BDNF Stimulation | Strong | Stronger | Mild–Moderate |
| Cognitive Focus | Strong | Very Strong | Mild–Moderate |
| Stress Resilience | Moderate | Moderate | Strong |
| Sedation Risk | None | None | None |
Semax is ideal for fast-acting nootropic support, while the amidated version is better suited for long-duration protocols.
Suggested Dosage & Protocol
Intranasal Use (Preferred):
- 300mcg to 600mcg per dose, 1–2 times daily
- Dosing in the morning and/or midday is ideal
- Typical cycle duration: 10–30 days
Subcutaneous Injection (less common):
- 100–300mcg once or twice daily
- Useful in acute protocols or experimental dosing models
Safety Profile of Semax
Semax is clinically used in Russia and is known for its excellent safety profile and lack of systemic side effects.
Common Observations:
- Increased clarity, improved focus, better mood
- Enhanced learning retention and mental speed
Rare Side Effects:
- Mild nasal irritation (intranasal use)
- Temporary overstimulation at very high doses
- No hormonal disruption, sedation, or dependency
Reference:
- Ashmarin IP et al., “Semax, An ACTH(4-10) Analogue with Nootropic Properties.” Neurochemical Research, 2005. https://link.springer.com/article/10.1007/s11064-005-8826-8
Storage Instructions
- Store lyophilized Semax at 2–8°C in a cool, dark location
- Reconstitute with bacteriostatic water or sterile saline
- Use within 14–30 days of reconstitution; refrigerate between uses
Ideal Stack Pairings
Semax is commonly paired with:
- Selank – for balanced mood and stress resilience
- DSIP – for post-stimulation sleep recovery and circadian support
- NAD+ – to enhance cellular energy during intense cognitive workloads
- P21 – for advanced neuroplasticity and cognitive regeneration
Is Semax Right for Your Research?
If your study focuses on cognition, neuroplasticity, recovery from brain fatigue, or neural repair, Semax is a versatile, fast-acting peptide with broad applications. Its non-stimulant profile and targeted cognitive action make it a staple in modern neuropeptide research.
Final Thoughts
Semax is a reliable and well-characterized nootropic peptide. Whether used to enhance mental clarity or support recovery from stress or neurological damage, it delivers brain-boosting benefits without toxicity or sedation.
Lab of RAD offers high-purity Semax peptide for advanced nootropic and neuroregenerative research.
⚠️ FDA Disclaimer
This content is provided for educational and research purposes only. Semax has not been evaluated or approved by the U.S. Food and Drug Administration (FDA). It is not intended to diagnose, treat, cure, or prevent any disease.
Lab of RAD peptides are sold for laboratory research use only and are not for human consumption.